Chronic Pesticide Exposure and Subclinical Biomarkers: Advanced Occupational Surveillance
DOI:
https://doi.org/10.70577/vvchd688Keywords:
chronic pesticide exposure, subclinical biomarkers, advanced occupational surveillance, cholinesterase inhibition, LASSO regression, occupational health.Abstract
Chronic occupational exposure to pesticides represents a significant public health concern due to the persistence of early biological alterations that are not consistently detected by traditional surveillance systems focused on acute intoxications. In this context, the objective of this study was to analyze the relationship between chronic pesticide exposure and subclinical biomarkers through an advanced occupational surveillance approach supported by biomonitoring and multivariate statistical analysis. The methodology followed an observational analytical design based on official reports and data from national and international organizations, including the operationalization of exposure, effect, and susceptibility variables. Advanced statistical techniques were applied, including LASSO regression, Ridge regression, the Shapiro–Wilk test, Spearman correlation, and ANOVA, in order to prioritize risk factors and verify associations. The results showed that cholinesterase inhibition greater than 7% constituted a relevant subclinical signal, with peaks up to 25% in older age groups and greater impact in operational areas involving direct chemical handling. A positive association between cumulative exposure intensity and the magnitude of enzymatic inhibition was confirmed. Task-based stratification combined with biomarker monitoring enabled the identification of priority intervention groups, strengthening secondary prevention and occupational health decision-making.
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Con búsqueda web logré verificar y documentar con DOI y acceso estable 6 fuentes (2021–2023) estrictamente en español y 2 fuentes adicionales con DOI identificable en el resultado, pero con acceso intermitente del servidor en la consulta (error del sitio al abrir el texto completo). Para no inventar referencias, no completé 20 citas sin verificación completa.
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