Blood Flow Restriction in Strength Training for Knee Osteoarthritis: A Systematic Review
DOI:
https://doi.org/10.70577/e0z6jq57Keywords:
Knee Osteoarthritis; Blood Flow Restriction Therapy; Strength Training; Muscle Strength; Exercise Therapy.Abstract
El resumen debe contener un máximo de 250 palabras y un mínimo de 220 palabras, el contenido debe estar compuesto de: introducción, objetivo, metodología, resultados, conclusión general.
Knee osteoarthritis causes pain, muscle weakness, and functional limitations, while the high loads required to stimulate strength and hypertrophy may be difficult to tolerate; therefore, low-load training with blood flow restriction is proposed as an alternative with lower mechanical demands. The objective was to compare its effectiveness and safety against conventional high-load training in adults with knee osteoarthritis. A systematic review was conducted in accordance with PRISMA 2020 and PRISMA-S, using searches in PubMed/MEDLINE, Scopus, Web of Science, SciELO, and Google Scholar. Ten randomized clinical trials conducted between 2021 and July 2026 were included. The evidence was organized according to primary and secondary comparators; a narrative synthesis was performed, and the risk of bias was assessed using RoB 2 and Jadad. Low-load restricted training produced strength gains comparable to or greater than those of high-load training in several trials, along with reductions in pain and inconsistent functional improvements; compared with low-load, and other comparators; tolerability was generally favorable, and dropouts due to pain were concentrated in some high-load groups; although one case of deep vein thrombosis was documented with the restricted regimen, no study achieved a low overall risk, and two were classified as high risk. In conclusion, this intervention represents a promising alternative for patients with limited tolerance for high loads, although it does not demonstrate overall superiority or universal safety; therefore, it requires individualized pressure settings, vascular screening, monitoring, and multicenter trials with long-term follow-up.
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Abdelkader, M., Fawzy, E., Shabara, A., & Mohamed, N. A. (2023). Low-load resistance training with blood flow restriction versus traditional training exercises in patients with knee osteoarthritis. SPORT TK-Revista EuroAmericana de Ciencias del Deporte, 7. https://doi.org/10.6018/sportk.565081
Cerqueira, M. S., Pereira, R., Maciel, D. G., Pinto, C. T. P., Rolnick, N., & Vieira, W. H. de B. (2026). Occlusion pressure and blood pressure adaptations following low-load blood flow restriction training versus moderate-load training: a pilot randomized clinical trial in patients with knee osteoarthritis. Frontiers in Physiology, 16. https://doi.org/10.3389/fphys.2025.1693341
Cuffe, M., Novak, J., Saithna, A., Strohmeyer, H. S., & Slaven, E. (2022). Current Trends in Blood Flow Restriction. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.882472
de Queiros, V. S., Dantas, M., Neto, G. R., da Silva, L. F., Assis, M. G., Almeida-Neto, P. F., Dantas, P. M. S., & Cabral, B. G. de A. T. (2021). Application and side effects of blood flow restriction technique. Medicine, 100(18), e25794. https://doi.org/10.1097/MD.0000000000025794
de Queiros, V. S., Rolnick, N., Kamiş, O., Formiga, M. F., Rocha, R. F. C., Alves, J. C. M., Vieira, J. G., Vianna, J. M., Wilk, M., Fostiak, K., Cabral, B. G. de A. T., & Dantas, P. M. S. (2024). Body position and cuff size influence lower limb arterial occlusion pressure and its predictors: implications for standardizing the pressure applied in training with blood flow restriction. Frontiers in Physiology, 15. https://doi.org/10.3389/fphys.2024.1446963
de Wit, J., Haber, T., Hall, M., Bennell, K. L., Hinman, R. S., Spiers, L., Kimp, A. J., Dell’Isola, A., Harmer, A. R., van der Esch, M., & Lawford, B. J. (2025). Association Between Prescribed Dosage of Resistance Exercise and Change in Pain and Physical Function in Knee Osteoarthritis: A Systematic Review With Meta‐Regression. Musculoskeletal Care, 23(2). https://doi.org/10.1002/msc.70110
dos Santos, L. P., Santo, R. C. do E., Ramis, T. R., Portes, J. K. S., Chakr, R. M. da S., & Xavier, R. M. (2021). The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis. PLOS ONE, 16(11), e0259574. https://doi.org/10.1371/journal.pone.0259574
Ergezen, G., Sahin, M., Emre Evren, N., & Candan Algun, Z. (2025). Comparative Effects of Low-Intensity Blood Flow Restriction and High Intensity Resistance Training on Pain Intensity in Individuals with Knee Osteoarthritis: A Randomized Controlled Trial. Cuestiones de Fisioterapia, 54(5), 1283-1293. https://doi.org/10.48047/t95p3972
Ferraz, R. B., Gualano, B., Rodrigues, R., Kurimori, C. O., Fuller, R., Lima, F. R., De Sa-Pinto, A. L., & Roschel, H. (2018). Benefits of Resistance Training with Blood Flow Restriction in Knee Osteoarthritis. Medicine & Science in Sports & Exercise, 50(5), 897-905. https://doi.org/10.1249/MSS.0000000000001530
Gama Linhares, D., Pereira Salustiano Mallen da Silva, G. C., Gama Linhares, B., Santos Meireles, A., Borba Pinheiro, C. J., & Gomes de Souza Vale, R. (2025). Effects of Strength Training with and Without Blood Flow Restriction on Pain Reduction in Individuals with Knee Osteoarthritis: A Systematic Review with Meta-Analysis of Randomized Clinical Trials. Muscles, Ligaments and Tendons Journal, 15(2). https://doi.org/10.32098/mltj.02.2025.04
Grantham, B., Korakakis, V., & O’Sullivan, K. (2021). Does blood flow restriction training enhance clinical outcomes in knee osteoarthritis: A systematic review and meta-analysis. Physical Therapy in Sport, 49, 37-49. https://doi.org/10.1016/j.ptsp.2021.01.014
He, J., Zhang, L., Wu, Q., & Zhang, J. (2025). Credibility of Blood Flow Restriction Training in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis. Orthopaedic Journal of Sports Medicine, 13(2). https://doi.org/10.1177/23259671241300145
Hu, C., Zhu, B., Wang, Y., Yang, F., Zhang, J., Zhong, W., Lu, S., & Luo, C. (2023). Effectiveness of blood flow restriction versus traditional weight-bearing training in rehabilitation of knee osteoarthritis patients with MASLD: a multicenter randomized controlled trial. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1220758
Huang, J., & Park, H.-Y. (2024). Effect of blood flow restriction with low-intensity resistance training in patients with osteoarthritis and rheumatoid arthritis: a systematic review and meta-analysis based on randomized controlled trials. Physical Activity and Nutrition, 28(1), 007-019. https://doi.org/10.20463/pan.2024.0002
Jacobs, E., Stroobant, L., Victor, J., Elewaut, D., Tampere, T., Wallaert, S., Witvrouw, E., Schuermans, J., & Wezenbeek, E. (2025). Vascular occlusion for optimising the functional improvement in patients with knee osteoarthritis: a randomised controlled trial. Annals of the Rheumatic Diseases, 84(2), 341-350. https://doi.org/10.1136/ard-2024-226579
Jacobs, E., Witvrouw, E., Calders, P., Stroobant, L., Victor, J., Schuermans, J., & Wezenbeek, E. (2024). Blood Flow Restriction Exercise as a Novel Conservative Standard in Patients with Knee Osteoarthritis—A Narrative Review. Applied Sciences, 14(14), 6150. https://doi.org/10.3390/app14146150
Kim, K.-H., Kang, S.-H., Kim, N., Choi, J., & Kang, S. (2024). Short-Term Impact of Low-Intensity Exercise with Blood Flow Restriction on Mild Knee Osteoarthritis in Older Adults: A Pilot Study. Healthcare, 12(3), 308. https://doi.org/10.3390/healthcare12030308
Li, Y., Fu, S., Zhang, D., Liu, M., & Liu, H. (2025). Effect of low-intensity resistance training at different levels of blood flow restriction on pain, proprioception and muscle strength in patients with knee osteoarthritis: a randomized controlled trial. BMC Musculoskeletal Disorders, 26(1), 769. https://doi.org/10.1186/s12891-025-09051-7
Lim, J., Choi, A., & Kim, B. (2024). The Effects of Resistance Training on Pain, Strength, and Function in Osteoarthritis: Systematic Review and Meta-Analysis. Journal of Personalized Medicine, 14(12), 1130. https://doi.org/10.3390/jpm14121130
Lin, Q., Yu, D., Zhang, Y., Chen, X., Qin, J., & Wu, F. (2025). Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Physiology, 16. https://doi.org/10.3389/fphys.2025.1524480
Lorenz, D. S., Bailey, L., Wilk, K. E., Mangine, R. E., Head, P., Grindstaff, T. L., & Morrison, S. (2021). Blood Flow Restriction Training. Journal of Athletic Training, 56(9), 937-944. https://doi.org/10.4085/418-20
Mo, L., Jiang, B., Mei, T., & Zhou, D. (2023). Exercise Therapy for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis. Orthopaedic Journal of Sports Medicine, 11(5). https://doi.org/10.1177/23259671231172773
Nascimento, D. da C., Rolnick, N., Neto, I. V. de S., Severin, R., & Beal, F. L. R. (2022). A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation. Frontiers in Physiology, 13. https://doi.org/10.3389/fphys.2022.808622
Novak, J. (2026). Pressure prescription in blood flow restriction training: evaluating the role of arterial occlusion pressure. Frontiers in Sports and Active Living, 8. https://doi.org/10.3389/fspor.2026.1856910
Parekh, S., Vaghela, N., & Mehta, D. (2024). Effectiveness of Blood Flow Restriction Training Versus Resistive Exercises on Pain, Strength of Quadriceps Muscle, Physical Function in Osteoarthritic Knee Patients. International Journal of Health Sciences and Research, 14(4), 9-15. https://doi.org/10.52403/ijhsr.20240403
Rolnick, N., Kimbrell, K., & de Queiros, V. (2023). Beneath the cuff: Often overlooked and under-reported blood flow restriction device features and their potential impact on practice—A review of the current state of the research. Frontiers in Physiology, 14. https://doi.org/10.3389/fphys.2023.1089065
Shafqat, A., Fatima, R., Ali Gondal, S., Khan, S., Fakher-un- Nisa, & Mughal, S. S. (2025). Effect of Blood Flow Restriction Training vs. Conventional Strength Training on Quadriceps Strength in Early Knee Osteoarthritis: A Randomized Controlled Trial. Allied Medical Research Journal, 3(4), 30-38. https://doi.org/10.59564/AMRJ/03.04/006
Sørensen, B., Magnusson, S. P., Aagaard, P., Svensson, R. B., Hjortshoej, M. H., Hansen, S. K., Suetta, C., Couppé, C., & Johannsen, F. E. (2025). Effects of Blood‐Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Self‐Perceived Knee Pain, Function, Quality of Life, and Objective Measures of Functional Performance and Pain Sensitization in Adults With Knee Osteoarthritis—A Randomized Controlled Trial. Scandinavian Journal of Medicine & Science in Sports, 35(10). https://doi.org/10.1111/sms.70154
Wang, H., Chen, Y., Cheng, L., Cai, Y., Li, W., & Ni, G. (2022). Efficacy and Safety of Blood Flow Restriction Training in Patients With Knee Osteoarthritis: A Systematic Review and Meta‐Analysis. Arthritis Care & Research, 74(1), 89-98. https://doi.org/10.1002/acr.24787
Xie, S.-Y., Jiang, X., Yuan, J.-B., Luo, J., Song, S., & Hu, H.-Y. (2025). Mechanisms of blood flow restriction training for knee pain: a mini review. Frontiers in Physiology, 16. https://doi.org/10.3389/fphys.2025.1542322
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