Impact Of Nutritional Interventions On Metabolic Control In Patients With Type 2 Diabetes Mellitus: A Systematic Review

Authors

DOI:

https://doi.org/10.70577/7g9kxq33

Keywords:

Impact, Nutritional interventions, Metabolic control, Type 2 diabetes mellitus.

Abstract

Type 2 diabetes mellitus is one of the major public health challenges worldwide due to its high prevalence, chronic progression, and association with complications that increase morbidity, mortality, and healthcare costs. In this context, metabolic control is a central goal of therapeutic management, with nutritional interventions being a key and potentially modifiable component of comprehensive treatment. The objective of this systematic review was to analyze the impact of nutritional interventions on metabolic control in adult patients with type 2 diabetes mellitus. Methodologically, a systematic review was conducted following the 2020 PRISMA guidelines. The literature search was performed in the PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect, SciELO, and Redalyc databases, including studies published between 2020 and 2025 in Spanish, English, and Portuguese. Fifteen scientific articles that met the inclusion criteria were selected, including clinical trials, systematic reviews, and meta-analyses that evaluated indicators such as glycated hemoglobin, fasting glucose, lipid profile, and body mass index. The results show that structured nutritional interventions, especially those based on healthy dietary patterns such as the Mediterranean diet, low-carbohydrate diets, plant-based approaches, and calorie restriction programs, produce significant improvements in metabolic control. Furthermore, it was identified that the personalization of nutritional therapy, adherence, nutrition education, and professional support are key factors in the magnitude and sustainability of the observed effects. In conclusion, nutritional interventions constitute an essential therapeutic pillar for metabolic control in type 2 diabetes mellitus; however, their effectiveness depends on comprehensive, sustained implementation adapted to the clinical and sociocultural context of the patients.

Downloads

Download data is not yet available.

References

Ajala, O., English, P., & Pinkney, J. (2021). Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes. The American Journal of Clinical Nutrition, 113(2), 316–329. https://doi.org/10.1093/ajcn/nqaa334 DOI: https://doi.org/10.1093/ajcn/nqaa334

American Diabetes Association. (2024). Standards of care in diabetes—2024. Diabetes Care, 47(Suppl. 1), S1–S350. https://doi.org/10.2337/dc24-Sint DOI: https://doi.org/10.2337/dc24-SINT

Esposito, K., Chiodini, P., Maiorino, M., Bellastella, G., Panagiotakos, D., & Giugliano, D. (2020). Which diet for prevention of type 2 diabetes? A meta-analysis of prospective studies. Endocrine, 67(2), 273–282. https://doi.org/10.1007/s12020-019-02105-0

Evert, A., Dennison, M., Gardner, C., Garvey, W., Lau, K., MacLeod, J., Mitri, J., Pereira, R., Rawlings, K., Robinson, S., Saslow, L., Uelmen, S., Urbanski, P., Yancy, W., & Dunbar, S. (2022). Nutrition therapy for adults with diabetes or prediabetes: A consensus report. Diabetes Care, 45(5), 1343–1382. https://doi.org/10.2337/dci22-0024

Goldenberg, J., Day, A., Brinkworth, G., Sato, J., Yamada, S., Jönsson, T., & Ebeling, P. (2021). Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: Systematic review and meta-analysis of published and unpublished randomized trials. BMJ, 372, m4743. https://doi.org/10.1136/bmj.m4743 DOI: https://doi.org/10.1136/bmj.m4743

Hernández-Ruiz, A., López-García, E., & Martínez-González, M. (2022). Intervenciones nutricionales y control metabólico en diabetes tipo 2: revisión de la evidencia. Revista Panamericana de Salud Pública, 46, e32. https://doi.org/10.26633/RPSP.2022.32 DOI: https://doi.org/10.26633/RPSP.2022.32

International Diabetes Federation. (2023). IDF diabetes atlas (10th ed.). International Diabetes Federation. https://diabetesatlas.org

Kahleova, H., Levin, S., & Barnard, N. (2020). Cardio-metabolic benefits of plant-based diets. Nutrients, 12(4), 1009. https://doi.org/10.3390/nu12041009 DOI: https://doi.org/10.3390/nu12041009

Lean, M., Leslie, W., Barnes, A., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K., Rodrigues, A., Rehackova, L., Adamson, A., Sniehotta, F., Mathers, J., Ross, H., & Taylor, R. (2020). Durability of a primary care–led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. The Lancet Diabetes & Endocrinology, 8(6), 477–489. https://doi.org/10.1016/S2213-8587(20)30068-4 DOI: https://doi.org/10.1016/S2213-8587(19)30068-3

McArdle, P., Greenfield, S., Rilstone, S., & Campbell, K. (2023). Dietary approaches for glycaemic control in type 2 diabetes: Current evidence and controversies. Nutrients, 15(6), 1412. https://doi.org/10.3390/nu15061412 DOI: https://doi.org/10.3390/nu15061412

Neuenschwander, M., Ballon, A., Weber, K., & Schlesinger, S. (2023). Dietary patterns and glycaemic control in type 2 diabetes: A systematic review and meta-analysis. European Journal of Epidemiology, 38(3), 243–256. https://doi.org/10.1007/s10654-022-00946-0

Pan, B., Wu, Y., Yang, Q., Ge, L., Gao, C., Xun, Y., & Chen, Y. (2022). Effect of nutrition education combined with dietary intervention on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 185, 109805. https://doi.org/10.1016/j.diabres.2022.109805 DOI: https://doi.org/10.1016/j.diabres.2022.109805

Papadaki, A., Martinez-Gonzalez, M., Alonso-Gomez, A., Rekondo, J., Salas-Salvado, J., Corella, D., Ros, E., Fito, M., Estruch, R., & Martinez, J. (2020). Mediterranean diet and glycemic control in type 2 diabetes: A randomized controlled trial. Diabetes Care, 43(2), 438–445. https://doi.org/10.2337/dc19-0875

Qian, F., Liu, G., Hu, F., Bhupathiraju, S., & Sun, Q. (2020). Association between plant-based dietary patterns and risk of type 2 diabetes: A systematic review and meta-analysis. JAMA Internal Medicine, 180(10), 1335–1345. https://doi.org/10.1001/jamainternmed.2020.2195 DOI: https://doi.org/10.1001/jamainternmed.2019.2195

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A., Ogurtsova, K., Shaw, J., Bright, D., & Williams, R. (2021). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045. The Lancet Diabetes & Endocrinology, 9(2), 107–112. https://doi.org/10.1016/S2213-8587(20)30312-3 DOI: https://doi.org/10.1016/j.diabres.2019.107843

Schwingshackl, L., Chaimani, A., Hoffmann, G., Schwedhelm, C., & Boeing, H. (2020). Impact of different dietary approaches on glycemic control in patients with type 2 diabetes: A systematic review and network meta-analysis. BMJ, 369, m696. https://doi.org/10.1136/bmj.m696 DOI: https://doi.org/10.1136/bmj.m696

Vitale, M., Masulli, M., Calabrese, I., Rivellese, A., & Vaccaro, O. (2021). Nutrition and diabetes: An update. Nutrients, 13(2), 396. https://doi.org/10.3390/nu13020396 DOI: https://doi.org/10.3390/nu13020396

Zhu, Y., Zhang, C., Liu, Y., Wang, P., & Sun, J. (2021). Low glycemic index diets and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis. Nutrients, 13(6), 1919.

Downloads

Published

2026-09-08

How to Cite

Impact Of Nutritional Interventions On Metabolic Control In Patients With Type 2 Diabetes Mellitus: A Systematic Review. (2026). Salud Medicina E Innovación Journal, 4(3), 948-968. https://doi.org/10.70577/7g9kxq33

Similar Articles

1-10 of 160

You may also start an advanced similarity search for this article.